10 best anti-ageing serums that target wrinkles, dark spots and dullness

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Once upon a simpler time, we cleansed, toned and moisturised. Today, there is a new step to add to that skin-enhancing list: anti-ageing serums. Specialist, potent treatments that aim to turn back the clock, by helping to erase crow’s feet, wrinkles, dryness and melasma (pigmentation from sun damage), they contain a concentrated amount of high-performing active ingredients. They come in small bottles and have a light-as-a-feather consistency, unlike heavy-duty moisturisers.

Most of the serums chosen below contain a cocktail of acids, vitamins, omega oils and collagen peptides. Vitamin C in particular can reduce pigmentation, while peptides are strings of molecules called amino acids, which are the "building blocks" of healthy skin. Hyaluronic acid is also a major component of skin, involved in repairing tissue, and omega oils are naturally occurring and hydrate skin. These have been shown to help reverse the effects of ageing, benefitting and plumping the surface, making wrinkles appear diminished and smoothing the skin with their exfoliating, softening powers. 

Use a pea-sized amount, as they are concentrates, so a little goes a long way. In terms of bang for your buck, formulas can cost anything from £12 up to almost £150, but which ones are worth the money? Scroll on, to find out.

How I tested

I assessed each serum over a three-week period

I assessed each serum over a three-week period (Jane Druker)

I tested each of the reviewed products for at least three weeks. I used some daily in the morning and evening, others twice weekly – both of which are recommended by the beauty glitterati. Some formulas are historical favourites of mine and others are brand new. As they have high-potency ingredients, build up to using twice daily over a few weeks (especially if you have sensitive skin) and target specific areas – lines, crow’s feet, wrinkles and dry spots or melasma – instead, to see a positive, swift difference.

Why you can trust IndyBest reviews

Jane Druker is an experienced beauty editor who has written for the likes of Vogue, The Telegraph and, of course, The Independent. Well placed to discuss anti-ageing skincare, she’s covered everything from tinted moisturisers for mature skin to anti-ageing night creams. She knows the brands that do and don’t work when it comes to minimising, fine lines, wrinkles and hyperpigmentation, and will only recommend products she believes are worth your money.

The best anti-ageing serums for 2025 are:

  • Best overall – Q&A collagen booster serum: £12, Amazon.co.uk
  • Best for dark spots – Cetaphil healthy radiance brightening serum: £30, Boots.com
  • Best for 50+ skin – Skinceuticals P-Tiox wrinkle-modulating peptide serum: £130, Facethefuture.co.uk
  • Best makeup artist favourite – Estee Lauder advanced night repair multi recovery serum: £89, Boots.com
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